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Generic propecia in the united states ) [3] that have been shown to prevent human pregnancy and reduce spontaneous abortion, thereby increasing the chances for continuation of pregnancy, although there are some reports of an increase in the risk of perinatal mortality in some cases of pregnancy [8], [9]. In the recent years, various studies on the effects of long-term use oral contraceptives have reported that (OCs) or combined oral contraceptive pills (COCs) have no statistically significant effects on the risk of gestating a live infant with low birth weight [10–15]. In the U.S., where OCs are classified as a category I drug, the risks of adverse health effects, including an increased risk of cancer including leukemia, are considered to be relatively small and are considered safe for use by young women [16]. In Europe, on the other hand, OCs are classified as a class I drug, thus conferring a higher risk of adverse effects [16]. In particular, the risks of adverse health effects due to the combined of OCs with estrogen are considered to be of a considerable magnitude, although with no clear evidence for increased risks of breast or ovarian cancer [17]. In our study, we did not find any difference in the risk of pregnancy between three OC categories (oral, intrauterine system, vaginal) when the women were between 1 and 12 years of age with a mean 1.5 years of age when they started to use the OCs. On other hand, if the women were between 13 and 18 years of age started to use OCs in mid-cycle, an increased risk of spontaneous abortion (the most common reason women decide to stop using the contraceptives) was noted, but only in women with oral contraceptives higher estrogen content in them (category I OC). The main strength of this study is that the data we collected during a prospective period of 4 years are based not only on the use of different OCs, but also on data from the mothers' medical record. However, we were not able to control for the level of estrogen intake, and, thus, there are some limitations concerning the use of hormonal variations during the study period. However, with respect to the study of Männistö, and all other studies on fertility and ovarian cancer, there was an almost identical distribution of total intake all major hormones, and we also found a significant decrease in intake of estradiol during the early part of period. data from the maternal medical record for every study subject were compared to the Finnish database, which has information as far back 1996 and includes the information on both contraceptive and the outcome of pregnancy. A detailed discussion this method of study design and statistical analyses is presented in a previous report [18]. The main strengths of current study include the prospective nature.

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